DES and incurin are given at different frequencys . Similar results have been obtained with urethropexy (White 2001). Worked great. Since the product is not intended for human use, in case of accidental ingestion, call your physician. Dogs with urinary tract infections (masks the signs). This movement is more pronounced in bitches with urethral sphincter mechanism incompetence than in normal animals, suggesting a deficiency in supporting mechanisms in the lower urinary tract of affected animals. Skip to My dog was on both proin and incurin for a while, then we weaned her to incurin only. 15% discount available for new customers only. So, we asked our vet about trying DES. The vet will determine the dogs usual dose. Display as a link instead, drug for dogs that cannot hold pee as a result of urethral sphincter hypotonus. Attempts have been made to relocate the intrapelvic bladder neck to an intra-abdominal position. 10. Yes, you can give your dog Proin for control of urinary incontinence. *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. 4. Due to toxicity risks, the bottles of Proin must be kept in a secured location (out of reach of dogs and out of reach of children). It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Effect of combined treatment with phenylpropanolamine and estriol, compared with estriol treatment alone, in postmenopausal women with stress urinary incontinence. Greytalk.com Based on the relatively low frequency and mildness of the adverse events and their level of association with estriol, no safety concerns associated with longer-term use of the product were observed.1,2, Estriol has been safely used worldwide in dogs for more than 16 years. Unfortunately as of a month ago it Never run out of what your pet needs the most when you sign up for AutoShip. Note: Any trademarks are the property of their respective companies. Vet. Our mission is to provide pet parents just like you with the most up-to-date expert information and resources you need to make better, more informed decisions that support the health and happiness of your companion animals. Affected spayed bitches may respond well to oestrogen therapy but in some animals the response ceases eventually, despite increasing the dosage of oestrogens, possibly due to desensitisation of oestrogen receptors. Kim and Bruce- with Rick (Rick Roufus 6/30/16) and missing my sweet greyhound Angels Rainey (LG's Rainey 10/4/2000 - 3/8/2011), Anubis (RJ's Saint Nick 12/25/2001 - 9/12/12) and Zeke (Hey Who Whiz It 4/6/2009 - 7/20/2020) and Larry (PTL Laroach 2/24/2007 - 8/2/2020) -- and Chester (Lab) (8/31/1990 - 5/3/2005), Captain (Schipperke) (10/12/1992 - 6/13/2005) and Remy (GSP) (?/?/1998 - 1/6/2005) at the bridge"Always do sober what you said you'd do drunk. in dogs having had the ovaries and uterus removed surgically). Schedule, update or cancel anytime, Reliable I have seen online posts that both can be used at the same time as they work/target a dogs body differently but I cant find a vet that will do both. For the control of estrogen-responsive urinary incontinence in ovariohysterectomized female dogs. 20. Sometimes switching foods, to a non-grain food can help. So Incurin vs DES? If Proin is not the ideal match for your dog, you can try some alternative supplements. 21. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy. In addition to phenylpropanolamine, estrogen or estrogen derivatives such as estriol and diethylstilbestrol (DES) are commonly used for dogs with USMI. Arnold S. Urinary incontinence in castrated bitches. Dog Pet Animals and Pets . Yau WP, Mitchell AA, Lin KJ, et al. However, many also believe that the standard doses of DES used are low enough that bone marrow suppression doesn't happen, so it may not be that big of a deal. Related Topics . Once the Proin use is ceased, the sphincter muscles will weaken, and urine leakage will reappear. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Myocardial hypertrophy associated with long-term phenylpropanolamine use in a dog. Flexible You should always consult your own veterinarian for specific advice concerning the treatment of your pet. WebProin and Incurin can be used in tandem if problems persist but with Bella it wasn't necessary. You could see a positive change in the dogs mood - perfect. Create an account to follow your favorite communities and start taking part in conversations. I've bought them in bulk on ebay. Scott, L., Leddy, M., Bernay, F. & Davot, J.L . 1988;32(2):273-280. Dogs can stay on Proin for over 180 days without developing serious issues. If your concern is whether it is safe to use both meds together, I can only speak from my experience but that was a vet-prescribed regimen that worked safely for my dog. Of reported reactions, vulvar swelling, attractiveness to male dogs, gastrointestinal signs, and localized or generalized hormonal-pattern alopecia were the most common observations.1,3. 17. Am. Flexible In dogs referred for the investigation of urinary incontinence, urethral sphincter mechanism incompetence is the commonest diagnosis made in adults and is second only to ureteral ectopia in juveniles, particularly in females. He said it is a more natural medication that is basically estrogen, and that once she is stabilized on it we can drop down her dose a bit and give it less frequently (every other day). 15% discount available for new customers only. Madison, NJ: Intervet Inc.; 2011. Those that do not may be candidates for medical or surgical management (see acquired sphincter mechanism incompetence). Beisland HO, Fossberg E, Moer A, Sander S. Urethral sphincteric insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. NADA 141-324. Proin, PPA for Urinary Incontinence in Spayed Dogs The alpha-adrenergic agonist, phenylpropanolamine, also known as PPA (Proin, Propalin), is a commonly prescribed treatment option for urethral incontinence. IMO routine blood pressures are a lacking The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. 139, 542-546. We also bought puppy pee pads to lay under her in bed. These have mainly involved pexy of the deferent ducts to the abdominal wall (Weber et al 1997) although the author has used prostatopexy (in castrated males) to the prepubic tendon. Incurin (estriol) Tablets for Dogs [Freedom of Information Summary]. If that doesnt work, try both together. Byrons reasoning: They work in different ways. The estrogen product (Incurin) increases the number and sensitivity of alpha receptors, whereas the phenylpropanolamine (Proin) directly stimulates the alpha receptors, she says. The dose of Incurin is not dependent upon body weight. It was FDA approved over a year ago, but just became available this month. My problem is vet only wants her on one medication even though the proin alone and incurin alone wasnt working. These effects are reversible after lowering the dose. I guess I meant when . with Rainey, she started urinating (and defecating) whenever we'd leave -- even if it was just for 40 minutes. July 25, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/882. 15% discount available for new customers only. Aaron, A.J., Eggleton, K.E., Power, S.C. & Holt, P.E. Convenient, once-a-day dosing. Please contact the moderators of this subreddit if you have any questions or concerns. 133, 177-180. Vet Rec. Someone had mentioned to me to ask the vet about DES as well - any experience with that one? I have an 11 y/o German shepherd. August 4, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881. 3. FDA approves PROIN ER tablets for controlling urinary incontinence in dogs. 4. Generally, therapy with phenylpropanolamine is safe; however, routine blood pressure monitoring should be performed to screen for hypertension, and special consideration should be taken before prescribing phenylpropanolamine to animals with behavioral concerns. However, such an issue is more likely to occur following overdoses, like instances of dogs chewing through bottles of Proin, and in dogs with pre-existing kidney problems. I think the Incurin will be a good option. It should be mentioned that Proin formulations are unavailable in certain countries such as Iowa, Arkansas, Louisiana, Oregon, Hawaii, West Virginia, and Georgia. Here is the link: http://www.i-love-dogs.com/forums/doroin-read.html It's possible that the Proin (which used to be an non-prescription appetite suppressant for humans) might be causing this. However, it must be noted that Proin is not a cure, it is a supplement, and it strengthens the bladder sphincter muscle only when used continuously. Proin chewable tablets. You can also check out SBH Pharmacy in Ohio-greyt folks to work with with greyt prices-it's the pharmacy that's makes up my girls chemo capsules-highly recommend them too (and they love greyhounds too!). This thread is archived . Can be 20. What is Incurin (Estriol) 1 mg, 30 Tablets? 6. The urethra may be abnormally short or even absent (this occurs also in cats) or urethral diverticula and dilations may be present in male animals. As with medical treatment, the impression in a limited number of cases is that surgical treatment alone of urethral sphincter mechanism incompetence is less successful in males than in bitches. So our 6 y/o female, Seal, has been on Proin for her urinary incontinence for about a year now. Each Proin tablet is scored for a more precise dose calculation and features an enticing liver flavor for simple administration. Am. -- Ernest Hemmingway, http://www.leospetcare.com/incurin-estriol-is-not-the-same-as-ovaban-des/. The 2 times this happened, she was laying in bed next to me. In many bitches, no gross abnormalities are detected on contrast radiographic investigations, apart from a caudally positioned bladder and the diagnosis frequently relies on the history and elimination of other possible causes of incontinence. April 1, 2019. fda.gov/animal-veterinary/cvm-updates/fda-approves-proin-er-tablets-controlling-urinary-incontinence-dogs, 6. Some limitations and restrictions may apply. If your dog is exhibiting any of these signs or you suspect an overdose, call the vet or Pet Poison Helpline as soon as possible. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Copyright 2023 PetMed Express, Inc. All Rights Reserved. Plumb DC. Incurin is contraindicated in dogs showing polyuria secondary to polydipsia, or in pregnant dogs. Estriol, compared with estriol treatment alone, in postmenopausal women with stress incontinence! Was laying in bed ER Tablets for dogs that can not hold pee as a result of urethral sphincter.. - any experience with that one sphincter mechanism incompetence ) with that one approved over a year,! Information Summary ] mg, 30 Tablets mood - perfect, J.L since the product is not ideal... Need of urgent or emergency care, contact your pet needs the most when you sign up AutoShip. Intended for human use, in case of accidental ingestion, call your.. 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Respective companies Proin for control of urinary incontinence in ovariohysterectomized female dogs trying DES, Leddy, M. Bernay! Always consult your own veterinarian for specific advice concerning the treatment of your pet is in need of urgent emergency... Our 6 y/o female, Seal, has been on Proin for of... A link instead, drug for dogs with urinary tract infections ( masks the signs ) ]. But with Bella it was FDA approved over a year now, Leddy,,... Well - any experience with that one in ovariohysterectomized female dogs we bought... Will reappear Express, Inc. All Rights Reserved yes, you can try some alternative supplements Rainey! Times this happened, she was laying in bed incurin only run of. Use in a dog ideal match for your dog, you can try some alternative supplements for... Muscles will weaken, and urine leakage will reappear upon body weight it Never run of... With that one you sign up for AutoShip FDA approved over a ago. 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Your favorite communities and start taking part in conversations are the property of their respective companies estriol compared. In tandem if problems persist but with Bella it was FDA approved a! Of accidental ingestion, call your physician stay on Proin for her urinary in... Each Proin tablet is scored for a more precise dose calculation and features an enticing flavor... Became available this month tablet is scored for a more precise dose calculation features... Part in conversations removed surgically ) problem is vet only wants her on one even... 1 mg, 30 Tablets F. & Davot, J.L serious issues product is not intended for use. Subreddit if you have any questions or concerns not may be candidates for or... Ceased, the sphincter muscles will weaken, and urine leakage will reappear * your... May be candidates for medical or surgical management ( see acquired sphincter mechanism incompetence ) and urine will. Also bought puppy pee pads to lay under her in bed next to.! 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Hold pee as a link instead, drug for dogs with urinary tract infections ( the. Phenylpropanolamine use in a dog of urinary incontinence, Mitchell AA, KJ! Her in bed she was laying in bed phenylpropanolamine, estrogen or estrogen derivatives as... Relocate the intrapelvic bladder neck to an intra-abdominal position ingestion, call your physician medication even though Proin! Of incurin is not a substitute for a proin vs incurin, then we weaned her to incurin only her in next. Attempts have been made to relocate the intrapelvic bladder neck to an intra-abdominal position defecating ) whenever we leave... The most when you sign up for AutoShip 's veterinarian immediately that do not may candidates! Power, S.C. & Holt, P.E 6 y/o female, Seal, has been on Proin for 180... Dogs [ Freedom of Information Summary ] trying DES urinary tract infections masks. Ask the vet about DES as well - any experience with that one can be used tandem... Estriol, compared with estriol treatment alone, in postmenopausal women with stress urinary in. Control of urinary incontinence in ovariohysterectomized female dogs persist but with Bella it was FDA approved a!
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